Indianapolis Colts vs San Francisco 49ers

NFL - December 22, 2025 7:15 PM

Indianapolis Colts have a 27.8% of winning.
San Francisco 49ers have a 72.2% of winning.

Click on a line grade to learn more.

Indianapolis ColtsSan Francisco 49ers
27.8%
LineBreak
Even		Grade
Fanduel26027.8%B

Indianapolis Colts
260
Break Even27.8%
Probability27.8%
GradeB
For this to be profitable, the Indianapolis Colts must be more likely than 27.8% to win.
However, the calculated probability is 27.8%, less likely, giving this bet a B grade.
Ceasers25528.2%B

Indianapolis Colts
Ceasers255
Break Even28.2%
Probability27.8%
GradeB
For this to be profitable, the Indianapolis Colts must be more likely than 28.2% to win.
However, the calculated probability is 27.8%, less likely, giving this bet a B grade.
DraftKings24029.4%C

Indianapolis Colts
DraftKings240
Break Even29.4%
Probability27.8%
GradeC
For this to be profitable, the Indianapolis Colts must be more likely than 29.4% to win.
However, the calculated probability is 27.8%, less likely, giving this bet a C grade.
BetRivers24029.4%C

Indianapolis Colts
BetRivers240
Break Even29.4%
Probability27.8%
GradeC
For this to be profitable, the Indianapolis Colts must be more likely than 29.4% to win.
However, the calculated probability is 27.8%, less likely, giving this bet a C grade.
MyBookie22031.2%F

Indianapolis Colts
MyBookie220
Break Even31.2%
Probability27.8%
GradeF
For this to be profitable, the Indianapolis Colts must be more likely than 31.2% to win.
However, the calculated probability is 27.8%, less likely, giving this bet a F grade.
72.2%
LineBreak
Even		Grade
DraftKings-29874.9%F

San Francisco 49ers
DraftKings-298
Break Even74.9%
Probability72.2%
GradeF
For this to be profitable, the San Francisco 49ers must be more likely than 74.9% to win.
However, the calculated probability is 72.2%, less likely, giving this bet a F grade.
MyBookie-31075.6%F

San Francisco 49ers
MyBookie-310
Break Even75.6%
Probability72.2%
GradeF
For this to be profitable, the San Francisco 49ers must be more likely than 75.6% to win.
However, the calculated probability is 72.2%, less likely, giving this bet a F grade.
Fanduel-32076.2%F

San Francisco 49ers
-320
Break Even76.2%
Probability72.2%
GradeF
For this to be profitable, the San Francisco 49ers must be more likely than 76.2% to win.
However, the calculated probability is 72.2%, less likely, giving this bet a F grade.
Ceasers-32076.2%F

San Francisco 49ers
Ceasers-320
Break Even76.2%
Probability72.2%
GradeF
For this to be profitable, the San Francisco 49ers must be more likely than 76.2% to win.
However, the calculated probability is 72.2%, less likely, giving this bet a F grade.
BetRivers-33577.0%F

San Francisco 49ers
BetRivers-335
Break Even77.0%
Probability72.2%
GradeF
For this to be profitable, the San Francisco 49ers must be more likely than 77.0% to win.
However, the calculated probability is 72.2%, less likely, giving this bet a F grade.

Spreads:

49.3% chance that Indianapolis Colts win or are within 6.5 points of winning.
50.7% chance that San Francisco 49ers win by 6.5 or more points.

Click on a line grade to learn more.

Indianapolis Colts (6.5)San Francisco 49ers (-6.5)
49.3%
LineBreak
Even		Grade
Lowvig10349.3%A-

Indianapolis Colts (6.5)
103
Break Even49.3%
Probability49.3%
GradeA-
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 49.3% to win.
However, the calculated probability is 49.3%, more likely, giving this bet a A- grade.
BetUS10050.0%C

Indianapolis Colts (6.5)
BetUS100
Break Even50.0%
Probability49.3%
GradeC
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 50.0% to win.
However, the calculated probability is 49.3%, less likely, giving this bet a C grade.
Betonline.ag-10250.5%C

Indianapolis Colts (6.5)
Betonline.ag-102
Break Even50.5%
Probability49.3%
GradeC
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 50.5% to win.
However, the calculated probability is 49.3%, less likely, giving this bet a C grade.
Ceasers-10952.2%F

Indianapolis Colts (6.5)
Ceasers-109
Break Even52.2%
Probability49.3%
GradeF
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 52.2% to win.
However, the calculated probability is 49.3%, less likely, giving this bet a F grade.
Fanduel-11052.4%F

Indianapolis Colts (6.5)
-110
Break Even52.4%
Probability49.3%
GradeF
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 49.3%, less likely, giving this bet a F grade.
DraftKings-11052.4%F

Indianapolis Colts (6.5)
DraftKings-110
Break Even52.4%
Probability49.3%
GradeF
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 49.3%, less likely, giving this bet a F grade.
MyBookie-11052.4%F

Indianapolis Colts (6.5)
MyBookie-110
Break Even52.4%
Probability49.3%
GradeF
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 49.3%, less likely, giving this bet a F grade.
BetRivers-11553.5%F

Indianapolis Colts (6.5)
BetRivers-115
Break Even53.5%
Probability49.3%
GradeF
For this to be profitable, the Indianapolis Colts (6.5) spread must be more likely than 53.5% to win.
However, the calculated probability is 49.3%, less likely, giving this bet a F grade.
50.7%
LineBreak
Even		Grade
Fanduel-11052.4%C

San Francisco 49ers (-6.5)
-110
Break Even52.4%
Probability50.7%
GradeC
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a C grade.
DraftKings-11052.4%C

San Francisco 49ers (-6.5)
DraftKings-110
Break Even52.4%
Probability50.7%
GradeC
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a C grade.
Ceasers-11052.4%C

San Francisco 49ers (-6.5)
Ceasers-110
Break Even52.4%
Probability50.7%
GradeC
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a C grade.
BetRivers-11052.4%C

San Francisco 49ers (-6.5)
BetRivers-110
Break Even52.4%
Probability50.7%
GradeC
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a C grade.
MyBookie-11052.4%C

San Francisco 49ers (-6.5)
MyBookie-110
Break Even52.4%
Probability50.7%
GradeC
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 52.4% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a C grade.
Lowvig-11453.3%F

San Francisco 49ers (-6.5)
-114
Break Even53.3%
Probability50.7%
GradeF
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 53.3% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a F grade.
Betonline.ag-11854.1%F

San Francisco 49ers (-6.5)
Betonline.ag-118
Break Even54.1%
Probability50.7%
GradeF
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 54.1% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a F grade.
BetUS-12054.5%F

San Francisco 49ers (-6.5)
BetUS-120
Break Even54.5%
Probability50.7%
GradeF
For this to be profitable, the San Francisco 49ers (-6.5) spread must be more likely than 54.5% to win.
However, the calculated probability is 50.7%, less likely, giving this bet a F grade.

Totals:

51.1% chance that the total final score will be over 45.5 points.
48.9% chance that the total final score will be under 45.5 points.

Click on a line grade to learn more.

Over (45.5)Under (45.5)
51.1%
LineBreak
Even		Grade
DraftKings-11553.5%F

Over (45.5)
DraftKings-115
Break Even53.5%
Probability51.1%
GradeF
For this to be profitable, the Over (45.5) must be more likely than 53.5% to win.
However, the calculated probability is 51.1%, less likely, giving this bet a F grade.
48.9%
LineBreak
Even		Grade
DraftKings-10551.2%F

Under (45.5)
DraftKings-105
Break Even51.2%
Probability48.9%
GradeF
For this to be profitable, the Under (45.5) must be more likely than 51.2% to win.
However, the calculated probability is 48.9%, less likely, giving this bet a F grade.

50.0% chance that the total final score will be over 46 points.
50.0% chance that the total final score will be under 46 points.

Click on a line grade to learn more.

Over (46)Under (46)
50.0%
LineBreak
Even		Grade
Lowvig-10751.7%C

Over (46)
-107
Break Even51.7%
Probability50.0%
GradeC
For this to be profitable, the Over (46) must be more likely than 51.7% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a C grade.
Ceasers-10952.2%F

Over (46)
Ceasers-109
Break Even52.2%
Probability50.0%
GradeF
For this to be profitable, the Over (46) must be more likely than 52.2% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.
BetUS-11052.4%F

Over (46)
BetUS-110
Break Even52.4%
Probability50.0%
GradeF
For this to be profitable, the Over (46) must be more likely than 52.4% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.
MyBookie-11052.4%F

Over (46)
MyBookie-110
Break Even52.4%
Probability50.0%
GradeF
For this to be profitable, the Over (46) must be more likely than 52.4% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.
Betonline.ag-11052.4%F

Over (46)
Betonline.ag-110
Break Even52.4%
Probability50.0%
GradeF
For this to be profitable, the Over (46) must be more likely than 52.4% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.
50.0%
LineBreak
Even		Grade
Lowvig-10751.7%C

Under (46)
-107
Break Even51.7%
Probability50.0%
GradeC
For this to be profitable, the Under (46) must be more likely than 51.7% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a C grade.
Ceasers-11052.4%F

Under (46)
Ceasers-110
Break Even52.4%
Probability50.0%
GradeF
For this to be profitable, the Under (46) must be more likely than 52.4% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.
BetUS-11052.4%F

Under (46)
BetUS-110
Break Even52.4%
Probability50.0%
GradeF
For this to be profitable, the Under (46) must be more likely than 52.4% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.
MyBookie-11052.4%F

Under (46)
MyBookie-110
Break Even52.4%
Probability50.0%
GradeF
For this to be profitable, the Under (46) must be more likely than 52.4% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.
Betonline.ag-11052.4%F

Under (46)
Betonline.ag-110
Break Even52.4%
Probability50.0%
GradeF
For this to be profitable, the Under (46) must be more likely than 52.4% to win.
However, the calculated probability is 50.0%, less likely, giving this bet a F grade.

49.0% chance that the total final score will be over 46.5 points.
51.0% chance that the total final score will be under 46.5 points.

Click on a line grade to learn more.

Over (46.5)Under (46.5)
49.0%
LineBreak
Even		Grade
Fanduel-10451.0%C

Over (46.5)
-104
Break Even51.0%
Probability49.0%
GradeC
For this to be profitable, the Over (46.5) must be more likely than 51.0% to win.
However, the calculated probability is 49.0%, less likely, giving this bet a C grade.
BetRivers-11052.4%F

Over (46.5)
BetRivers-110
Break Even52.4%
Probability49.0%
GradeF
For this to be profitable, the Over (46.5) must be more likely than 52.4% to win.
However, the calculated probability is 49.0%, less likely, giving this bet a F grade.
51.0%
LineBreak
Even		Grade
BetRivers-11553.5%F

Under (46.5)
BetRivers-115
Break Even53.5%
Probability51.0%
GradeF
For this to be profitable, the Under (46.5) must be more likely than 53.5% to win.
However, the calculated probability is 51.0%, less likely, giving this bet a F grade.
Fanduel-11854.1%F

Under (46.5)
-118
Break Even54.1%
Probability51.0%
GradeF
For this to be profitable, the Under (46.5) must be more likely than 54.1% to win.
However, the calculated probability is 51.0%, less likely, giving this bet a F grade.